中国科技论文在线

Two Hew bicyclic taxane diterpenoids. taxaehitrienes A(11 and B (21. were isolatedpom the needles of Taxus chinensis. Their structure were elucidated on the basis of spectroscopic data. The crystal structure of 2 was also presented. It is the fist timefor the isolation ofbicych'c diterpenoid which isproposed as the biogeneticprecursorfor taxanes.

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2005年05月31日

【期刊论文】Synthesis of the 2a-benzoylamido analogue of docetaxel

方唯硕， Wei-Shuo Fang， * Qi-Cheng Fang and Xiao-Tian Liang

Tetrahedron Letters 42(2001)1331-1333，-0001，（）：

-1年11月30日

摘要

—The 2a-benzoylamido analogue of docetaxel 2 was synthesized with a double inversion of the C-2 configuration as the key step, and its cytotoxic activity towards three tumor cell lines was tested. © 2001 Elsevier Science Ltd. All rights reserved.

paclitaxel， docetaxel， 2-benzoylamido analogue of docetaxel， SN2 double inversion.，

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2005年05月31日

【期刊论文】Synthesis and Cytotoxicity of 2-Amido Docetaxel Analogues

方唯硕， Wei-Shuo Fang， * Ying Liu， Hong-Yan Liu， Shao-Feng Xu， Liang Wang and Qi-Cheng Fang

Bioorganic & Medicinal Chemistry Letters 12(2002)1543-1546，-0001，（）：

-1年11月30日

摘要

—Various 2-amido docetaxel analogues were prepared and evaluated for their cytotoxicities. Among them, m-methoxy and m-chlorobenzoylamido analogues were most active but not superior to docetaxel and paclitaxel, and d-seco analogues inactive. Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines.