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周正洪, Zhuohong Yang, Zhenghong Zhou, Ke He, Lixin Wang, Guofeng Zhao, Qilin Zhou and Chuchi Tang
Tetrahedron: Asymmetry 14 (2003) 3937-3941,-0001,():
-1年11月30日
Some new chiral cyclic o-hydroxylarylphosphonodiamides were synthesized from (−)-α-phenylethylamine and found to be efficient ligands for the Ti(OPr-i )4 catalyzed asymmetric trimethylsilylcyanation of aromatic aldehydes. Corresponding cyanohydrins were obtained in good chemical yield and enantiomeric excesses up to 90%.
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周正洪, Ke He, Zhenghong Zhou, Lixin Wang, Kangying Li, Guofeng Zhao, Qilin Zhou and Chuchi Tang
Tetrahedron 60 (2004) 10505-10513,-0001,():
-1年11月30日
Some new chiral bifunctional o-hydroxyarylphosphonodiamides were synthesized starting from (+)-cis-1,2,2-trimethylcyclopentane-1,3-diamine and the absolute configuration of the phosphorus atom was determined by X-ray diffraction analysis. Excellent enantioselectivity (up to 98% ee) was achieved in asymmetric silylcyanation of aromatic aldehydes using a chiral titanium complex formed in situ from Ti(OiPr)4 and o-hydroxyarylphosphonodiamide as the catalyst.
Chiral cyclophosphonodiamide, Asymmetric silylcyanation, Catalysis, Enantioselectivity, Aromatic aldehyde
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周正洪, Zhou Zhenghong, Tang Yilong, Wang Lixin, Zhao Guofeng, Zhou Qilin, Tang Chuchi
SYNTHESIS 2004, No. 2, pp. 0217-0220,-0001,():
-1年11月30日
α-Disubstituted pyrrolidine-2-methanols were synthesized starting from L-proline and their application as chiral auxiliary in the asymmetric NaBH4 reduction of α,β-unsaturated triazolyl ketones was investigated. The corresponding α,β-unsaturated triazolyl alcohol derivatives (Uniconazole and Diniconazole) were obtained in good chemical yields with high ee values (up to 93%).
triazoles, L-proline, asymmetric reduction
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周正洪, Ke He, Zhenghong Zhou, Lixin Wang, Kangying Li, Guofeng Zhao, Qilin Zhou, Chuchi Tang
SYNLETT 2004, No. 9, pp. 1521-1524,-0001,():
-1年11月30日
A new chiral cyclic o-hydroxynaphthylphosphonodiamide (+)-2 was synthesized starting from (+)-cis-1,2,2-trimethylcyclopentane-1,3-diamine. The absolute configuration of phosphorus atom was determined as S by X-ray diffraction analysis. Excellent enantioselectivity (up to 98.3% ee) was achieved in asymmetric silylcyanation of aromatic aldehydes using a chiral titanium complex prepared in situ from Ti(Oi-Pr)4 and (+)-2 as the catalyst.
chiral phosphonodiamide, asymmetric silylcyanation, catalysis, enantioselectivity, aromatic aldehyde
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周正洪, Hongying Tang, Guofeng Zhao, Zhenghong Zhou, Qilin Zhou and Chuchi Tang
Tetrahedron Letters 47 (2006) 5717-5721,-0001,():
-1年11月30日
A chiral benzodiazepine derivative 1 was synthesized starting from o-nitrobenzoyl chloride and methyl L-prolinate hydrochloride. Diastereomeric (1R,2R,1’S)-(+)-2-[N-methyl-N-(α-phenylethyl)amino]cyclohexanol 3a and (1S,2S,1’S)-(+)-2-[N-methyl-N-(α-phenylethyl)amino]cyclohexanol 3b were synthesized starting from (S)-α-phenylethylamine and cyclohexene oxide via ringopening, diastereomer separation and N-methylation. (S,S)-octahydrodipyrrolo[1,2-a:1’,2’-d]pyrazin 5 was synthesized from methyl L-prolinate. Chiral tertiary amines 1, 3a, 3b and 5 almost cannot catalyze the Baylis–Hillman reaction between o-nitrobenzaldehyde and methyl vinyl ketone (MVK). However, they functioned as efficient catalysts for this reaction in the presence of L-proline. The corresponding adducts were obtained in good yields with enantioselectivity of 83% ee, 81% ee, 51% ee and 66% ee, respectively.
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