中国科技论文在线

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2009年04月28日

【期刊论文】Highly Enantioselective Synthesis of ç-Hydroxy-r,β-acetylenic Esters Catalyzed by a â-Sulfonamide Alcohol

余孝其， Li Lin， † Xianxing Jiang， † Weixia Liu， † Li Qiu， † Zhaoqing Xu， † Jiangke Xu， † Albert S. C. Chan， ‡ and Rui Wang*， †， ‡

ORGANIC LETTERS 2007 Vol. 9, No. 12 2329-2332，-0001，（）：

-1年11月30日

摘要

This work concerns the asymmetric addition of methyl propiolate to aldehydes with 1,2-dimethoxyethane (DME) as additive and

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2009年04月28日

【期刊论文】Dinuclear macrocyclic polyamine zinc (Ⅱ) complexes: Syntheses, characterization and their interaction with plasmid DNA

余孝其， Qing-Xiang Xiang a， Ji Zhang a， Pei-Yan Liu a， Chuan-Qin Xia a， Zhong-Yuan Zhou b， Ru-Gang Xie a， Xiao-Qi Yu a， *

Journal of Inorganic Biochemistry 99(2005)1661-1669，-0001，（）：

-1年11月30日

摘要

The syntheses, characteristics of dinuclear macrocyclic polyamine zinc complexes and their interaction with plasmid DNA are reported. The two cyclen (1,4,7,10-tetraazacyclododecane) moieties are bridged by rigid and flexible linkages. The crystal structures of Zn2C27H43N8O15Cl4 [5c•(ClO4)3•2H2O] and Zn2C30H43N10O13Cl3 [5e•(ClO4)3•H2O] have been determined. The complexes crystallize in the monoclinic space group C2/c and P2(1)/c with the following unit cell parameters: 5c• (ClO4)3 •2H2O: a=32.568(4) Å, b=14.8593(17) Å, c=19.443(2) Å, a=90.00º, b=119.435(4)º, c=90.00º, Dc=1.551 mg/m3, FW=956.71, F(000)=3932; 5e•(ClO4)3 Æ H2O: a=15.807(2) Å, b=16.756(2)Å, c=16.161(2) Å, a=90.00º, b=97.062(4)º, c=90.00º, Dc=1.546 mg/m3, FW=988.83, F(000)=2032. The distance between the two Zn(II) ions is about 4.0 Å. The structures show that two zinc ions can synergistically interact with the substrate DNA. With this novel structural characteristics, the dinuclear macrocyclic polyamine Zn(II) complexes via the synergetic effect between the two zinc ions can catalyze the cleavage of plasmid DNA (pUC18) with unprecedented speed at physiological conditions.

1,， 4,， 7,， 10-Tetraazacyclododecane (， cyclen)，， Macrocyclic polyamine， Dinuclear complexes， Synthesis， DNA cleavage

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2009年04月28日

【期刊论文】Highly diastereoselective epoxidation of cholest-5-ene derivatives catalyzed by polymer-supported manganese(Ⅲ) porphyrins

余孝其， Can-Ping Du， Zheng-Kai Li， Xiang-Min Wen， Jiang Wu， Xiao-Qi Yu∗， Meng Yang， Ru-Gang Xie

Journal of Molecular Catalysis A: Chemical 216(2004)7-12，-0001，（）：

-1年11月30日

摘要

Manganese(III) 5,10,15-tris(tolyl)-20-(4-hydroxyphenyl) porphyrin covalently attached to Merrifield's peptide resin (MPR) was prepared. The catalysts exhibit high reactivity and β-selectivity toward the epoxidation of cholest-5-ene derivatives with PhIO. Under mild reaction conditions, the catalyst was consecutively reused four times without detectable catalyst leaching and gave over 90% epoxide yield and over 99% β-selectivity.

Diastereoselective epoxidation， Cholest-5-ene derivatives， Supported metalloporphyrins

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2009年04月28日

【期刊论文】A simple copper salt catalysed the coupling of imidazole with arylboronic acids in protic solvent†

余孝其， Jing-Bo Lan， Li Chen， Xiao-Qi Yu， * Jing-Song You and Ru-Gang Xie*

Chem. Commun., 2004, 188-189，-0001，（）：

-1年11月30日

摘要

In the presence of a catalytic amount of a simple copper salt, the coupling of imidazole with arylboronic acids was performed in methanol to give corresponding N-arylimidazoles in almost quantitative yields; this coupling reaction could also be performed in aqueous solutions to give N-arylimidazoles in excellent yields.

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2009年04月28日

【期刊论文】Homochiral molecular tweezers as hosts for the highly enantioselective recognition of amino acid derivatives

余孝其， Can-Ping Du， a， b Jing-Song You， b Xiao-Qi Yu， b， * Chang-Lu Liu， b Jing-Bo Lana， b and Ru-Gang Xiea， *

Tetrahedron: Asymmetry 14(2003)3651-3656，-0001，（）：

-1年11月30日

摘要

Novel homochiral molecular tweezers comprised of two chiral macrocyclic polyamine skeletons have been developed. These homochiral artificial receptors exhibit excellent chiral recognition ability toward the enantiomers of L-and D-amino acid derivatives (up to KL/KD=7.9, ΔΔG0=−5.12 kJ mol−1) in CHCl3 at 25.0℃.

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