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【期刊论文】Hawthorn Fruit Is Hypolipidemic in Rabbits Fed a High Cholesterol Diet1
张泽生, Zesheng Zhang, Walter K. K. Ho, Yu Huang, * Anthony E. James, † Lik Wang Lam† and Zhen-Yu Chen
American Society for Nutritional Sciences. (2002) 5-10,-0001,():
-1年11月30日
The present study examined the hypolipidemic activity of hawthorn fruit. New Zealand white rabbits were fed one of three diets, a reference diet with no cholesterol added (NC), a high cholesterol diet (1g/100g, HC) and a HC diet supplemented with 2g/100g hawthorn fruit powder (HC-H). After 12 wk, serum total cholesterol (TC) and triacylglycerols (TG) were 23.4 and 22.2% lower, respectively, in the hawthorn fruit group compared with the HC rabbits (P﹤0.05). Hawthorn supplementation led to 50.6% less cholesterol accumulation in aorta (P﹤0.05) and 23-95% greater excretion of neutral and acidic sterols (P﹤0.05). Supplementation of hawthorn fruit did not affect the activities of hepatic 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG-CoA-R) or cholesterol 7 -hydroxylase (CH) but it suppressed the activity of intestinal acyl CoA:cholesterol acyltransferase (ACAT, P ﹤0.05). The results suggest that the mechanism by which hawthorn fruit decreases serum cholesterol involves, at least in part, the inhibition of cholesterol absorption mediated by down-regulation of intestinal ACAT activity. J. Nutr. 132: 5-10, 2002.
cholesterol, Crataegus pinnatifida, hawthorn fruit, rabbits, triglycerides
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张泽生, Zesheng Zhang a, Walter K.K. Ho a, Yu Huang b, Zhen-Yu Chen a, *
Z. Zhang et al./Food Research International 35(2002)885-891,-0001,():
-1年11月30日
The present study was to investigate the mechanisms by which hawthorn fruit lowers serum cholesterol in hamsters. The control group was fed a semisynthetic diet containing 0.1% cholesterol while the tested group was maintained on the same diet but supplemented with 0.5% hawthorn fruit aqueous ethanolic extract for 4 weeks. Serum total cholesterol (TC) and triacylglycerols (TG) were decreased by 10 and 13%, respectively, in hawthorn fruit group as compared with the control (P<0.05). Supplementation of hawthorn fruit aqueous ethanolic extract led to greater excretion of both neutral and acidic sterols. Further enzymatic assays suggest the mechanisms by which hawthorn fruit decreases serum cholesterol involve a greater excretion of bile acids mediated by up-regulation of hepatic cholesterol 7α-hydroxylase (CH) activity, and an inhibition of cholesterol absorption mediated by down-regulation of intestinal acyl CoA:cholesterol acyltransferase (ACAT) activity.
Cholesterol, Crataegus pinnatifida, Hawthorn fruit, Hamster, Triglyceride
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【期刊论文】Characterization of antioxidants present in hawthorn fruits
张泽生, Zesheng Zhang a, Qi Chang b, Min Zhu b, Yu Huang c, Walter K.K. Ho a, Zhen-Yu Chen a, *
Zhang et al./Journal of Nutritional Biochemistry 12(2001)144-152,-0001,():
-1年11月30日
Hawthorn fruit extract has been shown to have many health benefits including being cardiovascular protective, hypotensive and hypocholesterolemic. The present study was carried out to characterize further the antioxidants of hawthorn fruit and their effect on the oxidation of human low density lipoprotein (LDL) and α-tocopherol. The dry hawthorn fruit was extracted successively with ether, ethyl acetate, butanol and water. The ethyl acetate fraction was only effective in inhibition of Cu+2-mediated LDL oxidation. The column chromatographic separation led to isolation of eight pure compounds; namely, ursolic acid, hyperoside, isoquercitrin, epicatechin, chlorogenic acid, quercetin, rutin and protocatechuic acid. All of these phenolic compounds, except ursolic acid, were protective to human LDL from Cu+2-mediated LDL oxidation. They were also effective in preventing the peroxy free radical-induced oxidation of α-tocopherol in human LDL. The inhibitory effect of these compounds on oxidation of LDL and α-tocopherol was dose-dependent at concentrations ranging from 5 to 40µM. In addition, supplementation of 2% hawthorn fruit powder significantly elevated serum α-tocopherol by 18-20% in rats fed a 30% polyunsaturated canola oil diet, as compared with the control. The present results suggest that part of the mechanism for cardiovascular protective effects of hawthorn fruit might also involve the direct protection to human LDL from oxidation or indirect protection via maintaining the concentration of α-tocopherol in human LDL.
Flavonoid, Hawthorn fruit, Low density lipoprotein, α-Tocopherol
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【期刊论文】ENDOTHELIUM-DEPENDENT RELAXATION INDUCED BY HAWTHORN EXTRACT IN RAT MESENTERIC ARTERY
张泽生, Z.Y. Chen, Z.S. Zhang, K.Y. Kwan, M. Zhu, W.K.K. Ho, and Y. Huang
Hawthorn and Vasorelaxation 63 22(1998)1983-1991,-0001,():
-1年11月30日
The extract prepared from hawthorn (Crataegus fruit) was examined for its relaxant effect in rat isolated mesenteric arteries. Hawthorn extract induced concentrationdependent relaxation of the U46619-precontracted artery with an IC50 of 0.22
hawthorn, crataegus fruit, relaxation, endothelium, nitric oxide, artery
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【期刊论文】Theaflavins in Black Tea and Catechins in Green Tea Are Equally Effective Antioxidants1
张泽生, Lai Kwok Leung, Yalun Su, Ruoyun Chen, † Zesheng Zhang, Yu Huang* and Zhen-Yu Chen
American Society for Nutritional Sciences. (2001) 2248-2251,-0001,():
-1年11月30日
Green tea catechins, including (-)-epicatechin (EC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG), are oxidized and dimerized during the manufacture of black tea and oolong tea to form orange-red pigments, theaflavins (TF), a mixture of theaflavin (TF1), theaflavin-3-gallate (TF2A), theaflavin-3*-gallate (TF2B) and theaflavin-3,3*-digallate (TF3). The present study was designed to compare the antioxidant activities of individual TF with that of each catechin using human LDL oxidation as a model. All catechins and TF tested inhibited Cu12-mediated LDL oxidation. Analysis of the thiobarbituric acid-reactive substances (TBARS) and conjugated dienes produced during LDL oxidation revealed that the antioxidant activity was in the order: TF3>ECG>EGCG≥TF2B≥TF2A>TF1≥ EC>EGC. Four TF derivatives also demonstrated a dose-dependent antioxidant activity in Cu+2-mediated LDL oxidation at concentrations of 5-40mmol/L. These results demonstrate that the TF present in black tea possess at least the same antioxidant potency as catechins present in green tea, and that the conversion of catechins to TF during fermentation in making black tea does not alter significantly their freeradical-scavenging activity. J. Nutr. 131: 2248-2251, 2001.
black tea, catechins, green tea, low density lipoprotein, oxidation, theaflavins.,
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