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黄世文, HUANG Shiwen, FU Liezhen, ZHANG Xueqing, LIU Hui, LI Wenxin & ZHUO Renxi
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-1年11月30日
Polyamidoamine dendrimers using inositol as a core were designed, synthesized andcharacterized. The electrostatics interaction of PAMAM dendrimer with DNA causes the condensationof DNA to form DNA/dendrimer complexes. The sizes of complexes prepared from dendrimerG6 and pRE Luc at N/P ratio 10︰1 range from 80 to 300nm. Dendrimers G3 G6 are able toefficiently deliver pRE Luc and pSV-gal gene into HeLa and HEK 293 cells. The transfectionefficiencies of G5 and G6 are much higher than that of poly L-lysine (PLL) and comparable to that ofthe commercial branched polyethylenimine (PEI, Mw 25000), whereas the cytoctoxicities of G5 andG6 are lower than that of PLL.
polyamidoamine,, dendrimer,, gene transfer,, gene delivery.,
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