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王雪梅, Jingyuan Li, a, b Chunhui Wu, a Feng Gao, c Renyun Zhang, a Gang Lv, a Degang Fu, a Baoan Chenc and Xuemei Wanga, b, *
Bioorganic & Medicinal Chemistry Letters 16(2006)4808-4812,-0001,():
-1年11月30日
We report a novel approach to enhance the efficient accumulation and utilization of anticancer drug daunorubicin on cancer cells through the combination with CdS nanoparticles. Our observations using confocal fluorescence scanning microscopy as well as electrochemical analysis methods demonstrate that CdS nanoparticles can readily bind with daunorubicin on the external membrane of the targeted cells and facilitate the uptake of drug molecules in the human leukemia K562 cells. Besides, our results also indicate that the competitive binding of CdS nanoparticles with accompanying anticancer drug to the membrane of leukemia K562 cells could efficiently prevent the drug release by the drug-sensitive and drug-resistant leukemia cells and thus inhibit the possible multidrug resistance of cancer cells, which could be further utilized to improve the future drug efficiency in respective tumor chemotherapies.
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王雪梅, Min Song, Renyun Zhang, Xuemei Wang*
Materials Letters 60(2006)2143-2147,-0001,():
-1年11月30日
The biomolecular binding behavior of anticancer drug dacarbazine (DTIC) in the presence of titanium dioxide (TiO2) nanoparticle interface has been studied by using electrochemical methods. The results indicate that the presence of TiO2 nanoparticles can obviously increase the binding affinity of DTIC to DNA or DNA bases and significantly enhance the detection sensitivity for the relative biomolecular recognition.
Titanium dioxide, Nanomaterials, Electrochemistry, Biomolecular recognition, DNA
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【期刊论文】光谱法研究亚甲基绿(MG)、亚甲基蓝(MB)与DNA的识别作用及纳米材料对识别作用的影响
王雪梅, 张仁云, 王雪梅*, 平刚, 李尧
中国生物医学工程学报,2006,25(6):776~779,-0001,():
-1年11月30日
通过可见光谱法研究了亚甲基绿(MG)、亚甲基蓝(MB)与cT-DNA的相互作用,并且研究了纳米材料胶体金对该识别作用的影响。研究结果表明,MG、MB与DNA相互作用方式是不相同的,尽管它们在化学结构上只存在很小的差异。MG是以插入方式与DNA作用的,而MB与DNA作用存在沟槽和插入两种方式,并以沟槽方式为主。此外,通过在胶体金溶液中的研究表明,胶体金可以明显地提高小分子化合物与DNA作用检测的灵敏度。
光谱分析, DNA识别, 亚甲基绿, 亚甲基蓝, 胶体金
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王雪梅, Ren-Yun Zhang, Xue-Mei Wang*, Sheng-Jin Gong, and Nong-Yue He
Geno. Prot. Bioinfo. Vol. 3 No.1 2005,-0001,():
-1年11月30日
The study of small drug molecules interacting with nucleic acids is an area of intense research that has particular relevance in our understanding of relative mechanism in chemotherapeutic applications and the association between genetics (including sequence variation) and drug response. In this contribution, we demonstrate how the sequence-specic binding of an anticancer drug Dacarbazine (DTIC) to single base (A-G) mismatch could be sensitively detected by combining electrochemical detection with biosensing surface based on gold nanoparticles.
single base mismatch,, DTIC,, electrochemistry,, gold nanoparticles,, biosensor
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王雪梅, Xuemei Wang, Shiri Zeevi, Andrei B. Kharitonov, Eugenii Katz and Itamar Willner*
Phys. Chem. Chem. Phys., 2003, 5, 4236-4241,-0001,():
-1年11月30日
In situ electrochemical static contact angle measurements are employed to probe photoinduced electron transfer processes at electrode surfaces. Photosystems consisting of tris(2,20-bipyridyl)ruthenium(II), (Ru(bpy)32+), N,N0-dimethyl-4,40-bipyridinium (MV2+), Na2EDTA or CdS nanoparticles, MV2+, triethanolamine (TEOA) were included in aqueous droplets that were coupled with a ferrocene monolayer-functionalized electrode. Upon the oxidation of the interface (0.5 V vs. Ag quasi-reference electrode), and the illumination of the systems, photoinduced electron transfer to the modified electrode proceeds. The electron transfer processes yield photocurrents, and the photoelectrochemical transformations are followed by contact angle measurements. Similarly, a CdS/bipyridinium monolayer is assembled on an Au electrode support. The redox transformations of the bipyridinium units control the hydrophilic/hydrophobic properties of the interface, and are followed by contact angle analyses. Irradiation of the CdS/bipyridinium layer associated with the electrode biased at -0.3 V yields a photocurrent. The changes in the wetting properties of the irradiated interface are investigated by contact angle measurements.
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