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曲显俊, XIANJUN QU, YUNXIA YUAN, WENFANG XU, MINGHUI CHEN, SHUXIANG CUI, HONG MENG, YAN LI, MASATOSHI MAKUUCHI, MUNEHIRO NAKATA, and WEI TANG,
ANTICANCER RESEARCH 26: 3573-3578(2006),-0001,():
-1年11月30日
Abstract. Background: LY52 is a caffeoyl pyrrolidine derivative designed to fit and extend into the active pocket of matrix metalloproteinase (MMP). In this study, the effects of LY52 on MMP-2 and MMP-9 activities and tumor invasion and metastasis were examined. Materials and Methods: MMP expression in SKOV3 cells was analyzed by gelatin zymography. The anti-invasion and anti-metastasis abilities of LY52 were evaluated with penetration of SKOV3 cells through Matrigelcoated membrane in vitro and pulmonary metastasis of Lewis lung carcinoma in mice, respectively. Results: LY52 significantly blocked the proteolytic activity of gelatinase. Gelatin zymography revealed that MMP-2 and MMP-9 expressions in SKOV3 cells were reduced in the presence of LY52. LY52 also suppressed SKOV3 cell invasion in vitro. Furthermore, a significant inhibition of pulmonary metastasis of Lewis lung carcinoma cells was observed in LY52-administrated mice. Conclusion: LY52 might suppress invasion and metastasis of carcinoma cells via inhibition of MMP-2 and MMP-9 proteolytic activities.
LY52,, caffeoyl pyrrolidine derivative,, matrix metalloproteinase,, tumor invasion,, metastasis.,
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