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【期刊论文】Surface modification of biomaterials by plasma immersion ion implantation
黄楠, N. Huang*, P. Yang, Y.X. Leng, J. Wang, H. Sun, J.Y. Chen, G.J. Wan
Surface & Coatings Technology 186(2004)218-226,-0001,():
-1年11月30日
The present paper presents the results of surface modifications of biomaterials using plasma immersion ion implantation (PIII) in Institute of Surface Modification of Biomaterials in Southwest Jiaotong University. In the research, titanium oxide films and diamond-like carbon (DLC) films doped with different elements, as well as surface modification of polymers, are prepared using PIII. The blood compatibility of the films is investigated. Significant improvement in blood compatibility of the films compared with those untreated substrate materials is confirmed. The mechanisms of the blood compatibility of the films are discussed. The results show that the energy band structure of the material surface may be a controlling factor in the blood compatibility of the material. A film with an n-type semiconductor nature would have a better blood compatibility. Improvement in wear resistance of hip joint and modification of antibacterial property of artificial heart valve suture ring material is also presented in the paper.
Surface modification, Biomaterials, Biocompatibility, Plasma immersion ion implantation
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【期刊论文】In vivo study of Ti-O thin film fabricated by PIII
黄楠, P. Yang a, N. Huang a, *, Y.X. Leng a, J.Y. Chen a, H. Sun a, J. Wang a, F. Chen b, P.K. Chu c
Surface and Coatings Technology 156(2002)284-288,-0001,():
-1年11月30日
Over the past decade, much attention has been paid to anti-thrombotic materials applied in artificial organs. Surface modification has shown potential to improve the anti-coagulation of blood-contacting biomedical devices and materials w1-3x. Our in vitro study of Ti-O thin films has recently shown that Ti-O thin films possess superior blood compatibility to low temperature isotropic pyrolytic carbon (LTI-carbon), w1x. In this work, we have focussed our attention onto the in vivo evaluation of Ti-O thin films fabricated by plasma immersion ion implantation (PIII). The samples of titanium coated by Ti-O thin films were implanted in dogs'hearts for 1 month. The results of the implantation showed that no thrombus was found on the surfaces of the Ti-O thin film, although the coagulation occurred on the surfaces of LTI-carbon.
In vivo study, Blood compatibility, Biomaterial, Plasma immersion ion implantation (, PIII),
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【期刊论文】Hemocompatibility of titanium oxide films
黄楠, N. Huang a, b, *, P. Yang a, Y.X. Leng a, J.Y. Chen a, H. Suna, J. Wang a, G.J. Wang a, P.D. Ding b, T.F. Xi c, Y. Leng d
Biomaterials 24(2003)2177-2187,-0001,():
-1年11月30日
Hemocompatibility is a key property of biomaterials that come in contact with blood. Surface modification has shown great potential for improving the hemocompatibility of biomedical materials and devices. In this paper, we describe our work of improving hemocompatibility with Ti-O thin films prepared by plasma immersion ion implantation and deposition and by sputtering. The structure and surface chemical and physical properties of the films were characterized by X-ray diffraction, Auger electron spectroscopy, atomic force microscopy (AFM), contact angle measurement, and Hall effect measurement. The behavior of fibrinogen adsorption was investigated by 125I radioactive isotope labeling and AFM. Systematic evaluation of hemocompatibility, including in vitro clotting time, thrombin time, prethrombin time, platelet adhesion, and in vivo implantation into dog's ventral aorta or right auricle from 17 to 90 days, proved that Ti-O films have excellent hemocompatibility. It is suggested that the significantly lower interface tension between Ti-O films and blood and plasma proteins and the semiconducting nature of Ti-O films give them their improved hemocompatibility.
Titanium oxide film, Hemocompatibility, Interface tension, N-type semiconductor
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黄楠, N. Huang a, *, G.J. Wan a, Y. Leng b, Y.X. Leng a, H. Sun a, P. Yang a, J.Y. Chen a, J. Wang a, P.K. Chu c
Surface and Coatings Technology 156(2002)170-175,-0001,():
-1年11月30日
Plasma immersion ion implantation and deposition (PIIID) provides a novel approach to fabricate high quality films by means of utilizing particle filtrated metal plasma and varying acceleration pulse voltages. In this work, investigation on plastic deformation of TiN films synthesized by PIIID was performed by pulling the TiN film-coated stainless steel sheet samples. The surface morphology during the pulling was observed in situ by scanning electron microscopy. No elaminating, peeling or cracking werefound on the coating surfaces. The structure of the films was identified by transmission electron microscopy and atom force microscopy. It is considered that the excellent deformation behavior of the TiN film was related with the nanocrystal structure of the films and the broader filmymatrix interface achieved by the PIII process.
Deformation behavior, Titanium nitride film, Plasma immersion ion implantation
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黄楠, Huang Nan a, b, *, Yang Ping a, Cheng Xuan a, Leng Yongxang a, Zheng Xiaolan a, Cai Guangjun a, Zhen Zihong b, Zhang Feng b, Chen Yuanru a, Liu Xianghuai b, Xi Tingfei c
Biomaterials 19(1998)771-776,-0001,():
-1年11月30日
Titanium oxide films were synthesizedon titianium, cobalt alloy and low-temperature istropic pryolytic carbn by ion beam enhanced deposition. The non-stoichiometrical titanium oxide films were obtained. Blood compatibility of the films were evaluated by clotting time measurement, platelet adhesion in vestigation and hemlysis analyses. The results revealed that blood compatibility of the materials was improved by the coating of titanium oxide films. Semiconductor natute fo non-stoichiometric titanium oxide films might be responsible ofor the improvement of blood compatibility.
Blood compatibility, titanium oxide fiml, Ion beam enhanced deposition
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