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【期刊论文】Inhibition of adherent platelet activation produced by Ti-O thin film fabricated by PIII
黄楠, P. Yang, N. Huang*, Y.X. Leng, J.Y. Chen, H. Sun, J. Wang, G.J. Wan
Surface & Coatings Technology 186(2004)265-269,-0001,():
-1年11月30日
Thrombogenesis is the principal problem associated with blood-contacting biomedical devices. One of the important reasons is that most of the materials used in these devices cannot avoid inducing platelet adhesion and activation. Our recent investigation suggested that Ti-O thin film could be an alternative antithrombotic material. In this work, we focus our attention on behavior of platelets adhered on Ti-O film. Platelet adhesion experiments were conducted to examine the platelets/material interaction in vitro and the effect of protein adsorption on platelet adhesion and activation. The specific resultants of platelet release (GMP140) were tested for evaluating the platelet activation. In vivo implantation was used to investigate formation of thrombus. The excellent anticoagulation performance of Ti-O films has been shown in in vivo long-term mplantation. The release of specific resultants GMP140 from platelets contacting to Ti-O film was the lower than LTI-carbon. The morphology of adherent platelets maintainsround and isolated. Apparently, the activation of platelets adhered on Ti-O film was suppressed. The results of in vitro test also suggest that the suppression of platelet activation is related to plasma protein adsorption. Preadsorbing fibrinogen doesn't cause the exacerbation of platelet activation. It seems reasonable to suggest that its excellent anticoagulation is caused by inhibition of adherent platelet activation produced by Ti-O film.
Blood compatibility, Platelet activation, Protein adsorption, Ti-O film
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黄楠, F. Wen, N. Huang*, H. Sun, J. Wang, Y.X. Leng
Surface & Coatings Technology 186(2004)118-124,-0001,():
-1年11月30日
Nitrogen incorporated carbon films were synthesized using plasma immersion ion implantation and deposition at room temperature. Nitrogen partial pressure was varied from 1.0
Carbon nitride films, X-ray photoelectron spectrum, Raman spectrum, Optical band gap
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【期刊论文】STATE-OF-THE-ART OF SURFACE MODIFICATION OF BIOMATERIALS APPLIED FOR CARDIOVASCULAR DEVICES
黄楠, N. Huang, P. Yang, Y.X.Leng, L.J. Chen, H. Sun, J.Wang and G.J. Wan
Key note speaker on 3rd International conference on surface engineering, Sept. 10-13, 2002, Chengdu, China, pp 453-456,-0001,():
-1年11月30日
Surface modification has become a important field in biomaterials research because of the low cost, the high efficacy and the versatility. In this paper some recent applications of surface modification technology on the materials for cardiovascular devices were provided. Three ategories of the surface modification process, biological molecular immobilization, chemical medium binding and energy carrier substances coating or modification are discussed, the authors series work on the surface modification of artificial heart valve and vascular stents etc. are presented. The further development of the field is also discussed.
Surface modification,, Biomaterials,, cardiovascular devices Blood compatibility
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黄楠, G.J. Wan, N. Huang*, Y.X. Leng, P. Yang, J.Y. Chen, J. Wang, H. Sun
Surface & Coatings Technology 186(2004)136-140,-0001,():
-1年11月30日
TiN and Ti-O/TiN films have been deposited on Ti-6Al-4V substrate using plasma immersion ion implantation and deposition (PIII&D). It has been proved that TiN and Ti-O/TiN films both enhance the corrosion resistance of substrate materials. Potentiodynamic polarization curves show that both Ti-6Al-4V substrates deposited with these two kinds of films have lower dissolution urrents than that of the uncoated one. Electrochemical impedance spectroscopy (EIS) measurements indicates that TiN films with high corrosion resistance is mainly due to its barrier-type dense film layer, and that Ti-O/TiN film provides high corrosion resistance is mainly owing to its high corrosion potential (Ecorr). Friction coefficient curves obtained from pin-on-disk wear tests, as well as following SEM observation of wear residual trace width and morphology, indicate that TiN and Ti-O/TiN films both present high wear resistance in comparison with uncoated Ti-6Al-4V.
Corrosion and wear resistance, Titanium oxide, Titanium nitride, Plasma immersion ion implantation and deposition, Impedance spectroscopy
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【期刊论文】Surface Modification for Controlling the Blood-Materials Interface
黄楠, N.Huang, , a*, P. Yang, Y.X.Leng, J. Wang, J.Y. Chen, H. Sun, G.J. Wan, A.S. Zhao and P.D. Ding
Invited report on 6th Asia Symposium on Biomedical Materials, July 20-23, 2004,-0001,():
-1年11月30日
In the present paper, the scientific basis, technique approaches, the present status and the development trends of surface modification for blood contacting materials are discussed briefly. The work in authors' Lab. is also presented.
Biomaterials,, Surface Engineering,, Blood compatibility
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