中国科技论文在线

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2005年03月08日

曾益新，张林杰*，鄢践*，粱启万，黄必军，李辉梅，方嬿†

科学通报，2001，46（20）：1721～1724，-0001，（）：

-1年11月30日

以往研究提示，c-myc和c-erbB-2癌基因在鼻咽癌中过表达。为了阐明这两种癌基因过表达的分子机制，应用当前肿瘤研究新技术——组织微阵列，结合间期双色荧光原位杂交(FISH)和免疫组化(IHC)，对267例鼻咽癌组织、24例癌旁组织和29例鼻咽部慢性炎症组织进行了大样本研究。结果发现，号咽癌c-myc和c-erbB-2癌蛋白过表达发生率分别为48%￥～63%和20%～38%；但c-myc和c-erbB-2两个癌基因在鼻咽癌中均无扩增；8与17号着丝粒探针杂交则分别显示有43%～50%和20%～27%的鼻咽癌染色体呈现多体性。蛋白表达分析表明，c-erbB-2表达与17号染色体多体性有关（P<0.0005）。

鼻咽癌， c-myc， c-erbB-2，组织微阵列，染色体多体性

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2005年03月08日

【期刊论文】 Genetic Component Involved in Nasopharygeal Carcinoma Development

曾益新

，-0001，（）：

-1年11月30日

摘要

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2005年03月08日

【期刊论文】Familial nasopharyngeal carcinoma

曾益新， Yi-Xin Zeng* and Wei-Hua Jia

seminars in CANCER BIOLOGY, Vol. 12, 2002: pp. 443-450，-0001，（）：

-1年11月30日

摘要

Nasopharyngeal carcinoma (NPC) has a striking geographical and ethnical distribution. It occurs with high frequency in southern China and Southeast Asia. Family clustering was also observed in NPC and a typical family with 15 NPC cases was introduced in this paper. Epidemiological and genetic studies have been carried out in the previous decades and vast information was accumulated for familiar NPC, in terms of risk factors, inheritance mode, and involvement of gene polymorphisms. The major findings in this field were summarized. Furthermore, future directions leading to understanding the genetic mechanism of the familial form of NPC was also discussed.

Cantonese/， epidemiology/， familial/， nasopharyngeal carcinoma

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2005年03月08日

【期刊论文】Novel chromosomal alterations detected in primary nasopharyngeal carcinon by comparative genomic hybridization

曾益新， YAN Jian， FANG Yan， LIANC Qiwan， HUANC Yixue and ZENC Yixin

Chinese Medical Journal 2001; 114(4):418-421，-0001，（）：

-1年11月30日

摘要

Objective To gain a better understanding of genetic changes in Cantonese nasopharyngeal carcinoma (NPC). Methods Comparative genomic hybridization (CGH) was performed on 17 primary nasopharyngeal carcinomas.Results A novel copy number gain an chromosome 4q and loss of chromosome lp were found at a high frequency (>50%). Conclusions Current analysis revealed a comprehensive profile of the chromosomal regions showing gain of chromosomes 4q, 12q, and lq as well as loss of chromosomes 1p, 3p, 11q, 14q, 15q, 13q, Xq, 9q, 10p, 10q, and 16q. Frequently altered loci may encode oncogenes or tumor suppressor genes involved in the development of primary NPC.

nasopharyngeal carcinoma•comparative genornic hybridization•chromosomal alteration

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2005年03月08日

【期刊论文】Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4

曾益新， Bing Jian Feng*， Wei Huang， *， Yin Yao Shugart*， Ming K. Lee*， Feng Zhang*， Jian Chuan Xia， Hui Yun Wang， Teng Bo Huang， Shao Wen Jian， Ping Huang， Qi Sheng Feng， Li Xi Huang， Xing Juan Yu， Duang Li， Li Zheng Chen， Wei Hua Jia， Yan Fang， Hui Ming Huang， Jing Liu Zhu， Xiao Ming Liu， Yan Zhao， Wang Qing Liu， Mang Quan Deng， Wei Han Hu， Shao Xiong Wu， Hao Yuan Mo， Ming Fang Hong， Mary Claire King， Zhu Chen and Yi Xin Zeng

，-0001，（）：

-1年11月30日

摘要

Nasopharyngeal carcinoma (NPC) occurs with high frequency in Asian populations, especially among people of Cantonese ancestry. In areas with high incidence, NPC clusters in families, which suggests that both geography and genetics may influence disease risk1-6. Although the HLA-Bw46 locus is associated with increased risk of NPC7,8, no predisposing genes have been identified so far. Here we report the results of a genome-wide search carried out in families at high risk of NPC from Guangdong Province, China. Parametric analyses provide evidence of linkage to the D4S405 marker on chromosome 4 with a logarithm of odds for linkage (Iod) score of 3.06 and a heterogeneity-adjusted Iod (hlod) score of 3.21. Fine mapping with additional markers flanking D4S405 resulted in a lod score of 3.54 and hlod score of 3.67 for the region 4p15.1-q12. Multipoint nonparametric linkage analysis gives Iod scores of 3.54 at D4S405 (P=5.4

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