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2005年07月06日

【期刊论文】P(i-BuNCH2CH2)3N: An Efficient Ligand for the Direct α-Arylation of Nitriles with Aryl Bromides

游劲松， Jingsong You and John G. Verkade*

J. Org. Chem., Vol. 68, No.21, 2003，-0001，（）：

-1年11月30日

A new catalyst system for the synthesis of R-aryl-substituted nitriles is reported. The bicyclic triaminophosphine P(i-BuNCH2CH2) 3N (1b) serves as an efficient and versatile ligand for the palladium-catalyzed direct α-arylation of nitriles with aryl bromides. Using ligand 1b, ethyl cyanoacetate and primary as well as secondary nitriles are efficiently coupled with a wide variety of aryl bromides possessing electron-rich, electron-poor, electron-neutral, and sterically hindered groups.

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2005年07月06日

【期刊论文】The Inhibiting Influence of Aromatic Solvents on the Activity of Asymmetric Hydrogenations**

游劲松， Detlef Heller， * Hans-Joachim Drexler， Anke Spannenberg， Barbara Heller， Jingsong You， and Wolfgang Baumann*

Angew. Chem. Int. Ed. 2002, 41, No.5，-0001，（）：

-1年11月30日

摘要

Complexes of ruthenium, iridium, and especially rhodium have been used in the homogeneously catalyzed asymmetric hydrogenation of prochiral olefins, ketones, and imines. [1] Hydrogenations are usually carried out in simple alcohols, but aromatic solvents, water, or alcohol/aromatic solvent mixtures can also be used. It has been reported that aromatic solvents such as benzene can inhibit asymmetric hydrogena-phosphatase efficiently and selectively, thereby displaying the fundamental requirements for turnover-based enzyme inactivation.

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2005年07月06日

【期刊论文】Preparation and Asymmetric Hydrogenation of β-Aryl-Substituted b-Acylaminoacrylates**

游劲松， Jingsong You， Hans-Joachim Drexler， Songlin Zhang， Christine Fischer， and Detlef Heller*

Angew. Chem. Int. Ed. 2003, 42, No.8，-0001，（）：

-1年11月30日

摘要

The synthetic opportunities for the preparation of optically active b-amino acids are based mainly on stoichiometric reactions with chiral auxiliaries and to a significantly lesser