中国科技论文在线

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2006年10月31日

【期刊论文】OPmraeparation and Characterization of pH Sensitive Semi-interpenetrating Network Hydrogel Based on Methacrylic Acid, Bovine Serum Albumin (BSA), and PEG

钱志勇， GuoTao Chao，， HongXin Deng， †， Qiong Huang， WenJuan Jia， WanXia Huang， YingChun Gu， HePing Tan， LinYu Fan， CaiBing Liu， AnLiang Huang， Ke Lei， ChangYang Gong， MingJing Tu and ZhiYong Qian， *

Journal of Polymer Research (2006) 13: 349-355，-0001，（）：

-1年11月30日

摘要

In this article, a pH sensitive semi-interpenetrating network (SIPN) hydrogel based on methacrylic acid, BSA, and PEG was prepared by UV initiated free radical polymerization. The swelling behavior and pH sensitivity of these hydrogels were studied in detail. With the increase in pH of the aqueous solution from 1.7 to 9.23, the swelling ratio of these hydrogels increased accordingly. The effect of BSA and crosslinker (BIS) content on the swelling behavior was more complicated, and the results were shown in the text.

hydrogel， macromolecular drug delivery， responsive delivery systems， water absorption

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2006年10月31日

【期刊论文】Synthesis of Biodegradable Poly(butylene terephthalate)/poly(ethylene glycol) (PBT/PEG) Multiblock Copolymers and Preparation of Indirubin Loaded Microspheres†

钱志勇， Yan Wang， CaiBing Liu， LinYu Fan， Yong Sheng， Jian Mao， GuoTao Chao， Jun Li， MingJing Tu， ZhiYong Qian， *

Polymer Bulletin 53, 147-154 (2005)，-0001，（）：

-1年11月30日

摘要

Biodegradable PBT/PEG copolymers were synthesized by macromolecular transesterification method, and were characterized by 1H-NMR and DSC. Alkaline degradation behavior was studied too. Indirubin loaded microspheres were prepared by O/W solvent evaporation method.

multiblock copolymer， PBT/， PEG， poly(， ether ester)， s， microspheres

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2006年10月31日

【期刊论文】Synthesis and in vitro degradation study of poly(ethylene terephthalate)/poly(ethylene glycol) (PET/PEG) multiblock copolymer

钱志勇， ZhiYong Qian， Sai Li， Yi He， XiaoBo Liu*

Polymer Degradation and Stability 83 (2004) 93-100，-0001，（）：

-1年11月30日

摘要

Hydrolytically degradable PET/PEG block copolymer was synthesized by the macromolecular transesterification method from PET and PEG. Non-isothermal crystallization behavior of the copolymers was investigated by differential scanning calorimetry (DSC). Water absorption and in vitro degradation behaviour of these copolymers were studied in detail. When hydrophilic PEG was incorporated into the PET chain, water absorption increased. With the increase in PEG concentration, the degradation rate increased accordingly. PEG molecular weight has different effects on PET/PEG copolymers' degradation rate.

Block copolymer， PET/， PEG， Thermal property， Hydrolytic degradation， Poly(， ether-ester)， s

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2006年10月31日

【期刊论文】Thermal and hydrolytic degradation behaviour of degradable poly(etheresteramide) copolymers based on E-caprolactone, 11-aminoundecanoic acid, and poly(ethylene glycol)

钱志勇， ZhiYong Qian a， *， Sai Li b， Yi He b， Xiao Bo Liu b

Polymer Degradation and Stability 84 (2004) 41-47，-0001，（）：

-1年11月30日

摘要

A new kind of aliphatic polyetheresteramide copolymers (PEEAs) based on E-caprolactone, 11-aminoundecanoic acid, and poly(ethylene glycol) (PEG) were synthesized by melt polycondensation. The thermal and hydrolytic egradation behaviour of these copolymers was studied using FTIR, 1H-NMR, and TGA. PEG content, thickness of the test sample, and pH of degradation medium have great effect on degradation rate. The degradation rate increased with PEG content and pH, but decreased with thickness of the test sample.

Polyetheresteramide， Degradable polymer， Thermal degradation， Hydrolytic degradation， TG

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2006年10月31日

【期刊论文】Preparation of biodegradable polyesteramide microspheres

钱志勇， Zhiyong Qian， Sai Li， Yi He， Hailian Zhang， Xiaobo Liu

Colloid Polym Sci (2004) 282: 1083-1088，-0001，（）：

-1年11月30日

摘要

Biodegradable polyesteramide copolymer P(CL/AU) based on -caprolactone and 11-aminoundecanoic acid was synthesized by the melt polycondensation method. Polyesteramide (PEA) microspheres were prepared by a simple O/W emulsion solvent evaporation method. The effects of variations in preparation parameters (such as emulsifier concentration, polymer concentration, polymer solution adding rate, stirring rate, and whether vacuum was applied) were studied in detail. The obtained microsphere morphologies were observed using an optical microscope and via scanning electron microscopy (SEM). The particle size distribution was determined using a Malvern laser particle sizer. When the PEA microspheres were incubated in PBS saline, the particle size increased at first, and then decreased after a longer time period; the theory that this behavior was due to degradation of the microspheres was confirmed by SEM.

Polyesteramide， Microspheres， Solvent evaporation method， Surface morphology

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