中国科技论文在线

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2006年10月31日

【期刊论文】Preparation of biodegradable polyesteramide microspheres

钱志勇， Zhiyong Qian， Sai Li， Yi He， Hailian Zhang， Xiaobo Liu

Colloid Polym Sci (2004) 282: 1083-1088，-0001，（）：

-1年11月30日

Biodegradable polyesteramide copolymer P(CL/AU) based on -caprolactone and 11-aminoundecanoic acid was synthesized by the melt polycondensation method. Polyesteramide (PEA) microspheres were prepared by a simple O/W emulsion solvent evaporation method. The effects of variations in preparation parameters (such as emulsifier concentration, polymer concentration, polymer solution adding rate, stirring rate, and whether vacuum was applied) were studied in detail. The obtained microsphere morphologies were observed using an optical microscope and via scanning electron microscopy (SEM). The particle size distribution was determined using a Malvern laser particle sizer. When the PEA microspheres were incubated in PBS saline, the particle size increased at first, and then decreased after a longer time period; the theory that this behavior was due to degradation of the microspheres was confirmed by SEM.

Polyesteramide， Microspheres， Solvent evaporation method， Surface morphology

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2006年10月31日

【期刊论文】Synthesis of Biodegradable Poly(butylene terephthalate)/poly(ethylene glycol) (PBT/PEG) Multiblock Copolymers and Preparation of Indirubin Loaded Microspheres†

钱志勇， Yan Wang， CaiBing Liu， LinYu Fan， Yong Sheng， Jian Mao， GuoTao Chao， Jun Li， MingJing Tu， ZhiYong Qian， *

Polymer Bulletin 53, 147-154 (2005)，-0001，（）：

-1年11月30日

摘要

Biodegradable PBT/PEG copolymers were synthesized by macromolecular transesterification method, and were characterized by 1H-NMR and DSC. Alkaline degradation behavior was studied too. Indirubin loaded microspheres were prepared by O/W solvent evaporation method.

multiblock copolymer， PBT/， PEG， poly(， ether ester)， s， microspheres

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2006年10月31日

【期刊论文】Synthesis and thermal degradation of biodegradable polyesteramide based on e-caprolactone and 11-aminoundecanoic acid

钱志勇， Zhiyong Qian， Sai Li， Yi He， Cao Li， Xiaobo Liu*

Polymer Degradation and Stability 81 (2003) 279-286，-0001，（）：

-1年11月30日

摘要

A new kind of polyesteramide copolymer based on e-caprolactone and 11-aminoundecanoic acid has been synthesized by melt polycondensation. The copolymers were characterized by FTIR, 1H-NMR, DSC, and WAXD. With the increase in aminoundecanoic acid content, the melting temperature, heat of fusion, and Td,50% increased accordingly. The thermal degradation of the P(CL/AU)x/y copolymers was studied using FTIR, and TG During thermal degradation, the ester bond decomposes at lower temperature, then the amide bond decomposes at higher temperature.

Polyesteramide， Biodegradable polymer， Crystallinity， Thermal degradation， Nylon 11

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2006年10月31日

【期刊论文】Hydrolytic degradation behavior of biodegradable polyetheresteramide-based polyurethane copolymers

钱志勇， CaiBing Liu，， YingChun Gu， ZhiYong Qian， LinYu Fan， Jun Li， GuoTao Chao， MingJing Tu， WenJuan Jia

，-0001，（）：

-1年11月30日

摘要

In this article, a new kind of biodegradable polyetheresteramide-based polyurethane (PEEA-U) copolymers were prepared by the melt polycondensation method from -caprolactone, 6-aminocaproic acid, poly(ethylene glycol), and toluene diisocyanate. The water absorption of PEEA-U was affected strongly by the reaction time and the content of chain extender; and the hydrolytic degradation behavior of the copolymers was mainly determined by the reaction time, chain extender content, and the pH value of the degradation medium. Also, DSC, 1H-NMR, and inherent viscosity were used to characterize the degradation behavior of the copolymers.

biodegradable polymer， polyetheresteramide copolymer， polyurethane， degradation