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2006年07月06日

【期刊论文】1-甲基-3-乙基-3-(3羟基苯基)-六氢-1H-氮杂-卓盐酸盐的合成*

仇缀百，郝敬来，李炜，谢琼，陈燕，仇缀百△

复旦学报（医学版）2005，32（2）：173～177，-0001，（）：

-1年11月30日

摘要

Purpose To prepare 1-metyh1-3-ethy1-3(3-hydroxyhenyl)-hexahydro-1 H-azepin hy-drochloride (I) from m-methoxyacetophenone. Methods 1-methy1-3-(3-hydrox yphenyl)-hex-ahydro-1 H-azepin hydrochloride (I) was synthesized by eight steeps with m-methoxyacetophenone as start-ing material. The eight steps were willgerodt rearrangement, formation of acyl chloride, acylride and salt for-mation. Results 1-methy1-3-ethy1-3(3-hydroxypheny1)-hexahydro-1 H-azepin Hydrochlorde (I) was prepared in eight steps from cheap material and reagent on normal condition. Conclusions This method is applicable to industrial production.

1-甲基-3-乙基-3(， 3-羟基苯基)， -六氢-1H-氮杂盐酸盐，合成，缩合反应，乙基化反应，还原反应