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期刊论文

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2006年10月20日

【期刊论文】Effects of a plasmid expressing antisense tissue inhibitor of metalloproteinase-1 on liver fibrosis in rats

王吉耀， JIANG Wei， WANG Ji-yao， YANG Chang-qing， LIU Wen-bin， WANG Yi-qing and HE Bo-ming

Chin Med J 2005; 118 (3): 192-197，-0001，（）：

-1年11月30日

摘要

No efficient therapy for liver fibrosis has been available. This study was aimed to provide evidence that the introduction of a plasmid expressing antisense tissue inhibitor of metalloproteinase-1(TIMP-1) into a rat model of immunologically induced liver fibrosis can result in the increased activity of interstitial collagenase, thus enhancing the degradation of collagen.

liver fibrosis， antisense， tissue-inhibitor of metalloproteinase-1