中国科技论文在线

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2011年08月01日

【期刊论文】The ubiquitin ligase Hrd1 promotes degradation of the Z variant

沈玉先， Haiping Wang， Qi Li， Yujun Shen

，-0001，（）：

-1年11月30日

摘要

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2006年03月29日

【期刊论文】The protective effects of melatonin from oxidative damage induced by amyloid beta-peptide 25-35 in middle-aged rats

沈玉先， Y. X. Shen， S. Y. Xu， W. Wei， X. X. Sun， L. H. Liu， J. Yang and C. Dong

J. Pineal Res. 2002; 32: 85-89，-0001，（）：

-1年11月30日

摘要

This work investigated the ability of melatonin to prevent oxidative damage in brain tissue induced by injection of beta-amyloid peptide 25-35 (Ab25-35) in middle-aged rats. The Morris water maze was used to evaluate the cognitive function of the rats. Thiobarbituric acid-reactive substances and antioxidative enzymes (superoxide dismutase and glutathione peroxidase) activities were measured. It was found that injection of (Ab25-35) (20

antioxidative enzyme,， betaamyloid protein,， learning and memory,， lipid peroxidation,， melatonin

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2006年03月29日

【期刊论文】Protective effects of melatonin on cortico-hippocampal neurotoxicity induced by amyloid beta-peptide 25-351

沈玉先， SHEN Yu-Xian， WEI Wei， XU Shu-Yun

2002 Jam 23(1):71-76，-0001，（）：

-1年11月30日

摘要

To study the effects of melatonin on primary rat cortico-hippocampal neurotoxicity induced by amyloid beta-peptide 25-35. METHODS: The neuronal mor-phology was observed by phase-contrast microscopy. The iw.urotoxieity was quantitatively estimated by measur-ing laclate duhydrogenase (LDH) released into the culture medium from the damaged neurons. The neuronal metabolic state was quantified by the reduction of 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazo1ium bromide (MTr). RESULTS: Treatment ofprimary rat cortico-hipocampal neuonns with amyloid beta-peptide 25-35 (20 μmol/L) for 24h caused a significant decrease in neurocyte viability (P<0.01, compared with control). Melatonin (1 or 10 μmol/L) reduced the neurotoxicity induced by amyloid beta-peptidu 25-35. CONCLU-SION: Amyloid beta-peptide 25-35 could exert direct cytotoxicity on rat cortico-hippocampal neurocytes and melatonin concerdration-dependently rescued cultured neurons from exposure to amyloid beta-peptide 25-35 induced injury.

melatonin， neurons， amyloid beta-protein， lactate dehydrogenase

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2006年03月29日

【期刊论文】Protective effect of melatonin against liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide

沈玉先， Hua Wang， Wei Wei， Yu-Xian Shen， Chen Dong， Ling-Ling Zhang， Ni-Ping Wang， Li Yue， Shu-Yun Xu

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-1年11月30日

摘要

To investigate the effects and mechanisms of melatonin on immunological liver injury in mice.

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2006年03月29日

【期刊论文】Oral and nasal administration of chicken type II collagen suppresses adjuvant arthritis in rats with intestinal lesions induced by meloxicam

沈玉先， Yong-Qiu Zheng， Wei Wei， Yu-Xian Shen， Min Dai， Li-Hua Liu

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-1年11月30日

摘要

To investigate the curative effects of oral and nasal administration of chicken type II collagen (CII) on adjuvant arthritis (AA) in rats with meloxicam-induced intestinal lesions.

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