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马大龙, 武春晓), 石太平), )**
,-0001,():
-1年11月30日
人类基因组全序列的精细图已完成,当前生命科学面临的重要任务就是如何将基因组序列信息转化为基因的功能信息,了解生命活动的分子机理,改善人类健康,为生物技术发展提供动力。在一系列功能基因组研究新技术中,高通量(high-throughput)和高内涵(high-content)的细胞筛选技术平台已经显示出巨大潜力,发挥着越来越重要的作用。通过在体外培养的哺乳动物细胞中基因过表达或抑制基因表达,分析所产生信号传导通路和/或细胞表型改变,可以直接发现基因功能。近年来一些技术上的进展,使细胞筛选平台具有微量、自动、
功能基因组, 高通量, 高内涵, 细胞筛选技术
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【期刊论文】Overexpression of the novel human gene, nuclear apoptosis-inducing factor 1, induces apoptosis
马大龙, Bingfeng Lv a, b, , Taiping Shi c, Xinyu Wang c, Quansheng Song a, Yingmei Zhang b, Yan Shen c, d, Dalong Ma a, c, Yaxin Lou b, *
B. Lv et al./The International Journal of Biochemistry & Cell Biology 38 (2006) 671-683,-0001,():
-1年11月30日
Apoptosis is a genetically determined cell suicidal program that plays critical roles in many physiological and pathological processes. In this study, we report the cloning and characterization of a novel human gene, nuclear apoptosis-inducing factor 1 (N
Nuclear protein, Programmed cell death, Nuclear apoptosis-inducing factor 1, C9orf90, Homeodomain-like region
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【期刊论文】Nested genes in the human genome
马大龙, Peng Yu a, b, c, *, Dalong Ma a, Mingxu Xu a, ‡
Genomics 86 (2005) 414-422,-0001,():
-1年11月30日
Here we studied one special type of gene, i.e., the nested gene, in the human genome. We collected 373 reliably annotated nested genes. Two-thirds of them were on the strand opposite that of their host gene. About 58% coding nested gene pairs were conserv
Nested gene, Gene-within-a-gene, Overlapping gene, Evolution, Comparative analysis, Inverse expression
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