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已为您找到该学者14条结果 成果回收站

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2006年06月26日

【期刊论文】Silencing-specific methylation and single nucleotide polymorphism of hMLH1 promoter in gastric carcinomas

邓大君, Da-Jun Deng, Jin Zhou, Bu-Dong Zhu, Jia-Fu Ji, Jeffrey C. Harper, Steven M. Powell

World J Gastroenterol 2003; 9 (1): 26-29,-0001,():

-1年11月30日

摘要

AIM: To investigate CpG methylation and single nucleotidepolymorphism (SNP) of a specific promoter region of hMLH1in primary gastric carcinoma.METHODS: Primary gastric carcinomas (n=80), theircorresponding normal mucosal samples, and gastric mucosalbiopsi

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2006年06月26日

【期刊论文】Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas

邓大君, Daya Luo*, Baozhen Zhang*, Lingbo Lv, Shengyan Xiang, Yahang Liu, Jiafu Ji and Dajun Deng

,-0001,():

-1年11月30日

摘要

Inactivation of p16 by methylation of CpG islands is a frequent early event in gastric carcinogenesis. Thepositive relationship between p16 methylation and the clinical characteristics of gastric carcinomas (GC) hasnot been reported to date. In the presen

CpG Islands, DHPLC, gastric carcinoma, methylation, p16, quantification

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2006年06月26日

【期刊论文】progress of gastric cancer etiology: N-nitrosamides

邓大君, Da Jun Deng

World J Gastroentero, 2000; 6 (4): 613-618,-0001,():

-1年11月30日

摘要

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2006年06月26日

【期刊论文】p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N-nitro-N-nitrosoguanidine

邓大君, Hua Bai, Liankun Gu, Jing Zhou, Dajun Deng*

Mutation Research 535 (2003) 73-78,-0001,():

-1年11月30日

摘要

Inactivation of the tumor suppressor gene, p16 by CpG hypermethylation is a common event in various tumors includinggastric carcinoma. The aim of this study is to investigate if p16 hypermethylation is an early and frequent event in gastric carcinogenesis

CpG island, p16, Methylation, Wistar rat, Gastric carcinogenesis, Carcinogen, N-Nitroso compound

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2006年06月26日

【期刊论文】Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography

邓大君, Dajun Deng, , *, Guoren Deng, Michael F. Smith, Jing Zhou, Huijun Xin, Steven M. Powell and Youyong Lu

Nucleic Acids Research, 2002, Vol. 30, No.3 e13,-0001,():

-1年11月30日

摘要

We report here a novel method to simultaneouslydetect CpG methylation and single nucleotide polymorphisms(SNPs) using denaturing high performanceliquid chromatography (DHPLC). PCR products ofbisulfite-modified CpG islands were separated usingDHPLC. BstUI

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    北京大学,北京

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