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邓大君, Da-Jun Deng, Jin Zhou, Bu-Dong Zhu, Jia-Fu Ji, Jeffrey C. Harper, Steven M. Powell
World J Gastroenterol 2003; 9 (1): 26-29,-0001,():
-1年11月30日
AIM: To investigate CpG methylation and single nucleotidepolymorphism (SNP) of a specific promoter region of hMLH1in primary gastric carcinoma.METHODS: Primary gastric carcinomas (n=80), theircorresponding normal mucosal samples, and gastric mucosalbiopsi
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【期刊论文】Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas
邓大君, Daya Luo*, Baozhen Zhang*, Lingbo Lv, Shengyan Xiang, Yahang Liu, Jiafu Ji and Dajun Deng
,-0001,():
-1年11月30日
Inactivation of p16 by methylation of CpG islands is a frequent early event in gastric carcinogenesis. Thepositive relationship between p16 methylation and the clinical characteristics of gastric carcinomas (GC) hasnot been reported to date. In the presen
CpG Islands, DHPLC, gastric carcinoma, methylation, p16, quantification
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【期刊论文】progress of gastric cancer etiology: N-nitrosamides
邓大君, Da Jun Deng
World J Gastroentero, 2000; 6 (4): 613-618,-0001,():
-1年11月30日
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邓大君, Hua Bai, Liankun Gu, Jing Zhou, Dajun Deng*
Mutation Research 535 (2003) 73-78,-0001,():
-1年11月30日
Inactivation of the tumor suppressor gene, p16 by CpG hypermethylation is a common event in various tumors includinggastric carcinoma. The aim of this study is to investigate if p16 hypermethylation is an early and frequent event in gastric carcinogenesis
CpG island, p16, Methylation, Wistar rat, Gastric carcinogenesis, Carcinogen, N-Nitroso compound
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邓大君, Dajun Deng, , *, Guoren Deng, Michael F. Smith, Jing Zhou, Huijun Xin, Steven M. Powell and Youyong Lu
Nucleic Acids Research, 2002, Vol. 30, No.3 e13,-0001,():
-1年11月30日
We report here a novel method to simultaneouslydetect CpG methylation and single nucleotide polymorphisms(SNPs) using denaturing high performanceliquid chromatography (DHPLC). PCR products ofbisulfite-modified CpG islands were separated usingDHPLC. BstUI
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