Dissolvable Microneedles with Fucoidan and Te NPs for the Combination of Anti-Angiogenic and Photothermal Therapy of Melanoma

• 1、School of biomedical and pharmaceutical sciences, Guangdong University of Technology, Guangzhou 510006

Abstract：The incidence ofmelanoma has been increasing in recent years, and traditional therapies may be accompanied by serious side effects, limiting their clinical application. Melanoma need a lot of nutrients during the growth process, which will promote angiogenesis in the tumor area, and the microvascularity of the tumor is an important factor in promoting the metastasis of the tumor, so it is necessary to inhibit the microvascular formation at the tumor. The emerging photothermal therapy (PPT) and microneedle (MNs) have attracted the attention of researchers because of their non-invasive and controllable. We designed bovine serum albumin (BSA)-coated tellurium nanoparticles (Te NPs) and then combined Te NPs and Fucoidan (Fu) with poly(2-ethyl-2-oxazoline) (PetOx) dissolvable microneedles to obtain Te/Fu-PetOx MNs (TFu MNs) co-loaded with Fucoidan for the treatment of epidermal melanoma. This system used poly(2-ethyl-2-oxazoline) as a microneedle carrier with good skin penetration and excellent biocompatibility. Te NPs were used as photothermal materials with good photothermal conversion capability. Fucoidan, a natural substance derived from brown algae, is known to have activities such as anti-tumor and angiogenesis inhibition. The prepared TFu MNs can be administered transdermallyand can be used for photothermal therapy and inhibit tumor microangiogenesis to achieve single-dose treatment of melanoma, improve the cure rate of melanoma, and provide new ideas and methods for the clinical treatment of melanoma.

Keywords： Melanoma Photothermal therapy Antiangiogenesis Fucoidan