补阳还五汤抑制缺血再灌注肾损伤小鼠TGF-βSmad及PDGFERK通路活化

温庆思; 关卿; 周悦; 时研; 孙玉; 闫泽文; 林洪丽; 王大鹏

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Buyang-Huanwu decoction blocks TGF-β/Smad pathway by inhibiting FUT8 expression in IRI mice

首发时间：2024-04-08

WEN Qingsi ^{1
2}
Wen Qing-si (1998-),female,master candidate,main research interest is renal interstitial fibrosis
GUAN Qing
Guan Qing (1998-), female, master degree candidate, her research interest is chronic kidney disease.
ZHOU Yue SHI Yan SUN Yu YAN Zewen LIN Hongli
Hongli Lin, (1966-) female, Professor, Research interest in the mechanism of acute and chronic kidney disease
WANG Dapeng
Wang Dapeng, (born in 1978), male, Professor. His research interests include pathogenesis, diagnosis and treatment strategies of chronic kidney disease with integrated traditional Chinese and western medicine

1、Institude college of Integrative Medicine, Dalian Medical University, Dalian,Liaoning, 116044,China
2、Department of Nephrology, The First Affiliated Hospital, Dalian Medical University, Dalian,Liaoning,116011, China

Abstract： In order to elucidate the mechanism of Buyang-Huanwu decoction in TGF-β/Smad signaling pathway in AKI-to-CKD mice. We constructed animal model of AKI-to-CKD by renal ischemia-reperfusion injury (IRI). We grouped the mice, assessed renal function on the 30th day after modeling, tested the level of α-SMA and TGF-β/Smad pathways, and detected the changes of Fut8 and VEGF R2 levels and core fucosylation of TGF-βRⅡ. The results show that Buyang-Huanwu decoction also down-regulates the level of Fut8 and core fucosylation of TGF-βRII, up-regulates the level of VEGF R2, inhibits the activation of TGF-β/Smad, and eases the process of IRI. These data indicate that Buyang-Huanwu decoction could inhibit the activation of TGF-β/Smad pathway by inhibiting the Fut8 and then block the pathological process of AKI-to-CKD.

keywords： Buyang-Huanwu decoction AKI-to-CKD TGF-β/Smad Fut8 IRI core fucosylation 注：本文WEN Qingsi和GUAN Qing为共一作

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补阳还五汤抑制缺血再灌注肾损伤小鼠TGF-βSmad及PDGFERK通路活化

温庆思 ¹
Wen Qing-si (1998-),female,master candidate,main research interest is renal interstitial fibrosis
关卿 ¹
Guan Qing (1998-), female, master degree candidate, her research interest is chronic kidney disease.
周悦 ¹ 时研孙玉 闫泽文 林洪丽
Hongli Lin, (1966-) female, Professor, Research interest in the mechanism of acute and chronic kidney disease
王大鹏
Wang Dapeng, (born in 1978), male, Professor. His research interests include pathogenesis, diagnosis and treatment strategies of chronic kidney disease with integrated traditional Chinese and western medicine

1、大连医科大学中西医结合学院，辽宁大连116044

摘要：为明确小鼠肾脏AKI-to-CKD动物模型中，补阳还五汤调控TGF-β/Smad信号通路的糖生物学相关机制。通过肾脏缺血再灌注损伤（IRI）构建AKI-to-CKD的小鼠动物模型，分组后进行造模，于造模后第30天取材评估肾功能，测定α-SMA，TGF-β/Smad通路变化；并检测肾组织Fut8和VEGF-R2水平及TGF-βRII的核心岩藻糖基化变化。结果发现，补阳还五汤下调Fut8及TGF-βRII的核心岩藻糖基化，上调VEGF-R2水平保护PTC，抑制TGF-β/Smad通路活化，减缓缺血再灌注肾损伤进程，提示补阳还五汤可通过抑制Fut8进而阻断TGF-β/Smad通路活化，来阻断IRI小鼠AKI-to-CKD的病理过程。

关键词：补阳还五汤 AKI-to-CKD TGF-β/Smad Fut8 肾脏缺血再灌注损伤核心岩藻糖基化修饰

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WEN Qingsi,GUAN Qing,ZHOU Yue,et al. Buyang-Huanwu decoction blocks TGF-β/Smad pathway by inhibiting FUT8 expression in IRI mice[EB/OL]. Beijing:Sciencepaper Online[2024-04-08]. https://www.paper.edu.cn/releasepaper/content/202404-116.

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论文编号	202404-116
论文题目	补阳还五汤抑制缺血再灌注肾损伤小鼠TGF-βSmad及PDGFERK通路活化
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