Synthesis of acetylene modified paclitaxel derivatives

• 1、School of Pharmacy, Chongqing University，Chongqing City 400331

Abstract：Paclitaxel is a common anti-tumor drug in clinical practice, but it has many drawbacks that require modification and modification. The aim of this experiment is to couple paclitaxel and 4Coupling synthesis of paclitaxel and 4-pentyne acid-pentyne acid through esterification reaction to synthesize a new compound. Through this experiment, we hope to explore the synthesis method of the new compound and preliminarily evaluate its structure and potential biological activity. The synthesized product was characterized by liquid chromatography-mass spectrometry (LC-MS). The experimental results showed that the esterification coupling product of paclitaxel and 4-pentyne acid was successfully synthesized. The molecular weight matches the expected product, confirming the success of the synthesized compound. The successful synthesis of this compound provides a basis for further research on its biological activity and pharmacological properties. In addition, this experiment also demonstrated the importance of esterification reactions in organic synthesis and provided a method for further exploring the chemical modification and structural modification of paclitaxel.

Keywords： Medicinal chemistry Paclitaxel 4-Pentyne acid Esterification reaction