阳极氧化增材制造多孔Ti-6Al-4V植入体的早期抗菌行为
首发时间:2024-04-15
摘要:采用增材制造技术制备的多孔Ti-6Al-4V植入体可以更好地匹配人体骨骼的弹性模量,因此,常用于骨植入材料。然而,临床上,细菌感染常导致植入体松脱。为了改善多孔Ti-6Al-4V植入体的抗菌性能,本文利用阳极氧化技术对多孔Ti-6Al-4V植入体进行了表面纳米化改性,在不同氧化电压下制备了2种具有不同纳米管管径的样品,并对其形貌和早期抗菌性能进行了研究,同时简要讨论了其抗菌机理。结果表明,经过50 V氧化电压处理的样品在表面形成了管径约为50nm的二氧化钛纳米管阵列,该阵列在12小时内具有显著的抑制表面金黄色葡萄球菌吸附与增殖的效果。这一研究为未来进一步研究和临床应用奠定了基础。
关键词: 多孔Ti-6Al-4V植入体 阳极氧化 二氧化钛纳米管阵列 抗菌
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The antibacterial behavior of anodized porous Ti-6Al-4V implants fabricated by additive manufacturing
Abstract:Porous Ti-6Al-4V implants fabricatedbyadditive manufacturing techniques can better match the elastic modulus of human bone, and are therefore commonly used as bone implant materials. However, clinically, bacterial infections often lead to implant loosening.In order to improve the antimicrobial properties of porous Ti-6Al-4V implants, in this paper, the surface of porous Ti-6Al-4V implants was modified by surface nanosizing using anodic oxidation technique,and two kinds of samples with different nanotube diameters were prepared at different oxidation voltages, and their morphology and early antimicrobial properties were investigated, accompanied by a brief discussion of their antimicrobial mechanisms. The results showed that the samples treated with 50 V oxidation formed arrays of titanium dioxide nanotubes with tube diameters of about 50 nm on the surface, and the arrays had a significant inhibition of the adsorption and proliferation of Staphylococcus aureus on the surface within 12 h. This study lays the foundation for further research and clinical applications in the future.
Keywords: Porous Ti-6Al-4V implants Anodic oxidation Titania nanotube arrays Antibacterial
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阳极氧化增材制造多孔Ti-6Al-4V植入体的早期抗菌行为
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