白术化学成分及生物活性研究进展
首发时间:2024-04-03
摘要:菊科植物白术(Atractylodes macrocephala Koidz.)是一味经典的补益类中药,健脾益气,常用于治疗各种胃肠道疾病。白术的化学成分类型丰富,倍半萜内酯含量最高。迄今为止,从白术中分离出来的化合物约有140种,以倍半萜为主,还有聚乙炔、多糖、苯丙素以及少量黄酮和黄酮苷类化合物。研究表明,白术提取物和单体化合物表现出多种生物活性,包括调节胃肠道功能,抗炎、抗肿瘤、神经保护、调节免疫系统、抗氧化、抗骨质疏松和抗菌等,具有良好的药物开发前景。本文旨在对白术的化学成分和生物活性进行系统综述,为后续深入研究和临床应用提供理论依据。
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Progress on Chemical Constituents and Biological activities of Atractylodes macrocephala Koidz.
Abstract:Atractylodes macrocephala Koidz, a traditional Chinese medicine, is widely used to treat a variety of gastrointestinal disorders. A.macrocephala is rich in types of chemical constituents, with the highest content of sesquiterpene lactones. To date, about 145 compounds have been isolated from A. macrocephala, dominated by sesquiterpenes compounds, as well as polyacetylenes, polysaccharides, phenylpropanoids, flavonoids and flavonoid glycosides, etc.It also has a variety of biological activities, including the regulation of gastrointestinal function, anti-inflammatory, anti-tumor, neuroprotective, immune system modulation, antioxidant, anti-osteoporosis and anti-bacterial, etc. This paper is aimed to summarize the chemical compositions and pharmacological effects of A. macrocephala, which can provide a theoretical basis for subsequent in-depth research and clinical application.
Keywords: A. macrocephala Chemical constituents Biological activities Review
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