植物m6A阅读蛋白家族的功能研究
首发时间:2026-07-13
摘要:N6 -甲基腺苷(N6-methyladenosine, m6A)作为真核生物mRNA上最丰富的内部修饰,在植物基因表达调控中发挥着关键作用,参与调控植物生长发育过程与抗逆境胁迫等各个方面。m6A修饰是动态可逆的,其中,m6A阅读蛋白(readers)能够特异性识别携带甲基化修饰的转录本,对mRNA进行调控,是m6A修饰的核心效应因子。近年来,有关m6A修饰在植物中的研究取得了巨大进展,本文综述了植物中m6A阅读蛋白的成员、在植物生长发育和响应生物与非生物胁迫中发挥的重要功能,以及m6A阅读蛋白的协同调控因子,为开展m6A阅读蛋白的植物生理学研究、作物的遗传改良提供理论参考。
关键词: 分子生物学 m6A甲基化 m6A阅读蛋白 植物生长发育 非生物胁迫
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Overview of Punctional Research on Plant m6A Read Proteins Family
Abstract:N6-methyladenosine (m6A), the most abundant intramolecular modification on eukaryotic mRNA, plays a key role in the regulation of gene expression in plants, contributing to various aspects of plant growth, development, and stress response. The m6A modification is dynamically reversible; m6A readers are capable of specifically recognizing transcripts bearing this methylated modification and regulating mRNA, serving as the core effectors of m6A modification. In recent years, significant progress has been made in the study of m6A modification in plants. This review summarizes the members of the m6A reader family in plants, their important functions in plant growth, development, and responses to biotic and abiotic stresses, as well as the co-regulatory factors of m6A readers, providing a theoretical reference for conducting plant physiological research on m6A readers and for crop genetic improvement.
Keywords: Molecular biology M6A methylation M6A-binding proteins Plant growth and development Abiotic stress
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