There have been many papers concerning about the Peak to Average Power Ratio (PAPR) reduction and High Power Amplifier (HPA) linearization techniques for wireless OFDM communication systems. Few papers, however, make deep analysis on the relation between these two techniques. Based on Saleh’s memoryless Traveling Wave Tube Amplifier (TWTA) model, computer simulations and analysis in this paper demonstrates that, especially when the HPA is working near or in the saturation region, a predistorter will cease to be in effect. In such cases, PAPR reduction techniques may be resorted to help to improve the Adjacent Channel Interference (ACI), BER performances and HPA efficiency 1.