Bombyx mori silk fabrics were chemically modified by EPSIB (a multifunctional silicone-containing epoxy crosslinking agent). The reactivity of the epoxy groups with silk fibroin was studied by using amino acid analysis. The physical properties of the modified silks such as resiliency (both wet and dry), moisture regain, dyeing behaviors, and solubility in a mixture solvent (C2H5OH CaCl2: H2O 2: 1: 8, molar ratio) were examined. The modified silk fabrics exhibited a significantly improved resiliency, a small increase in moisture regain and whiteness, and a slightly decreased tensile strength. The contents of Serine, Trosine, Lysine, and Histidine decreased linearly as the wet crease recovery angle (CRA) increased. The solubility in the mixture solvent also decreased as the wet CRA increased. The changes of physical properties, especially the wet CRA, were mainly due to the presence of stable crosslinks between silk fibroin and epoxy groups. The DSC and TGA analyses showed that EPSIB-modified silk fibroin had a higher thermal stability compared with the control.