Microbes were cultured and identified from the samples collected at various depths in 4 weathering profiles of REE-bearing granites in Gonghe, Guangdong. The microbes were found existing at the depth of 0-5m in all the profiles. The main microbes include coccus (Staphylococcus, Streptococcus), bacillus (Bacillus, Clostridium and Escherichia Coli), actinomyces and fungi (Saccharomycete, Penicillium, Fusarium, Aspergillus Aiger and Mucor). The number of colonies decreases downwards in theprofiles. Experimental studies show that all the microbes used in the experiment can accelerate downward migration of REE in the experimental tubes. The ability to accelerate the migration of REE decreases in a sequence of fungi→actinomyces→bacillus→coccus. The microbes can change the modes of occurrence of REE in the weathering crust. The coccus, bacillus and actinomyces can increase the amounts of REE in ion state, whereas the fungi have a stronger ability to form organic compounding REE and accumulate REE than the bacteria do.