Enantioselective hydrogenation of ethyl pyruvate catalyzed by alumina support rhodium modiﬁed with quinine，成果详细信息-中国科技论文在线

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Enantioselective hydrogenation of ethyl pyruvate catalyzed by alumina support rhodium modiﬁed with quinine

陈华， Wei Xiong ， a ， b Hongxia Ma ， a Yanyi Hong ， a Hua Chena and Xianjun Lia ， *

Tetrahedron: Asymmetry 16 (2005) 1449-1452，-0001，（）：

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Alumina supported rhodium catalyst using cinchonidine as a stabilizer exhibited excellent performance in the asymmetric hydrogenation of ethyl pyruvate with the addition of quinine. Quinine as a chiral modiﬁer can not only induce the enantioselectivity, but also greatly accelerate the reaction. Under the optimum conditions: 293 K, 7.0 MPa of hydrogen pressure and 4.6×103 mol/L of quinine concentration in THF, TOF of Rh/2(cinchonidine)-c-Al2O3 as catalyst and ee value of (R)-ethyl lactate can achieve 894 h 1 and 71.6% ee, respectively.

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