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期刊论文

Determination of matrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies

陈兴国Xinan Wuab Fumiyoshi Yamashita b Mitsuru Hashida b Xingguo Chen a* Zhide Hua

Talanta 59(2003)965-971,-0001,():

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摘要/描述

A simple high-performance liquid chromatography (HPLC) method is described for the determination of matrine in rat plasma. The plasma was deproteinized with acetonitrile that contained an internal standard (phenacetin) and was separated from the aqueous layer by adding sodium chloride. Matrine was extracted into the acetonitrile layer with high yield, and determined by reversed-phase HPLC (column: YMC-pack ODS-A, 5mm, 150

关键词: Matrine HPLC-UV Rat plasma

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