DNA repair protein levels vis-a'-vis anticancer drug resistance in the human tumor cell lines of the National Cancer Institute drug screening program，成果详细信息-中国科技论文在线

陈忠平

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期刊论文

DNA repair protein levels vis-a'-vis anticancer drug resistance in the human tumor cell lines of the National Cancer Institute drug screening program

陈忠平， Zhiyuan Xu ，， Zhong-Ping Chen ， Areti Malapetsa ， Moulay Alaoui-Jamali ， Jose Bergeron ， Anne Monks ， Timothy G Myers ， Gerard Mohr ， Edward A Sausville ， Dominic A Scudiero ， Raquel Aloyz and Lawrence C Panasci

Anti-Cancer Drugs 2002, 13, pp. 511-519，-0001，（）：

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摘要/描述

Nucleotide excision repair (NER) is a multi-enzyme DNA repairpathway in eukaryotes. Several NER genes in this pathway includingXPB,XPD,XPAand ERCC-1have been implicated in anticancerdrug resistance in human tumor cells. In this study, we assessedthe levels of the above-mentioned proteins in the NCI panel of 60human tumor cell lines in relation to the cytotoxicity patterns of 170compounds that constitute the standard agent (SA) database.Thedatabase consists of drugs used in the clinic for which a mechanismofaction has been at least partially de

关键词: Bifunctional alkylating agent, DNA repair, drug resistance, endogenous protein, National Cancer Institute human cell line panel, nucleotide excision repair, xeroderma pigmentosumcomplementary group D ，

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