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期刊论文
Enantioselective cyanosilylation of ketones catalyzed by double-activation catalysts with N-oxides
J. Org. Chem., Vol. 70, No. 21, 2005,-0001,():
Enantioselective addition of trimethylsilyl cyanide to ketones by a catalytic double-activation method is described. By combinatorially using 2.0mol% of a chiral salen-titanium complex and 1.0mol% of an achiral tertiary amine N-oxide, aromatic, aliphatic and a,b-unsaturated ketones are converted into corresponding cyanohydrin trimethylsilyl ethers with 50-93% yield and 59-86% ee. The effects of ligand structure, catalyst loading and substrate concentration, solvents, the nature of Lewis base, counter ion and other additives, temperature, and substrate structure on the enantioselectivity are discussed. Three possible paths to achieve the asymmetric version of double-activation catalysis and two independent examples of it are proposed.
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