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期刊论文
2',3'-乙氧甲撑基腺苷5'-硫代磷酰氨基酸酯的合成和谱学分析
高等学校化学学报,2002,2284~2286,-0001,():
Nucleoside reverse transcriptase inhibitors are the only drugs so far approved for the treat-ment of AIDS. Several nucleoside analogs are potent inhibitors of human immunodeficiency virus (HIV) in cell culture. However, in many cases the nucleoside derivatives have a poor affinity for nu-cleoside kinases. Nucleoside 5'-phosphorothioates is relatively resistant to enzymatic transformations. In this paper, 2', 3'-O-alkoxymethylidene adenosine 5'-thiophosphoramidates were synthesized through a highly efficient approach. The new compounds were characterized by NMR, IR and ESI-MS.
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