Gene mutation of thiopurine S-methyltransferase in Uygur Chinese，成果详细信息-中国科技论文在线

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Gene mutation of thiopurine S-methyltransferase in Uygur Chinese

黄民， Jian-Ping Zhang ， Yong-Yuan Guan ， An-Long Xu ， Shu-Feng Zhou ， Jue-Heng Wu ， Hong Wei ， Min Huang

Eur J Clin Pharmacol (2004) 60: 1-3，-0001，（）：

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摘要/描述

Objective: This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese. Methods: Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations-G238C, G460A and A719G. Results: One TPMT*3A heterozygote and ﬁve TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively. Conclusion: TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese.

关键词: Thiopurine

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