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期刊论文
A flexible non-amino acid-based formal asymmetric synthesis of naturally occurring (2R,3S)-2-aminotetradeca-5,7-dien-3-ol: observation of a remarkable protecting group effect
Tetrahedron: Asymmentry 14(2003)2101-2108，-0001，（）：
A flexible non-amino acid-based formal asymmetric synthesis of naturally occurring antimicrobial (2R,3S)-2-aminotetradeca-5,7-dien-3-ol is reported. The method features a flexible and highly regioselective Grignard addition to (S)-malimide followed by a trans-diastereoselective reductive deoxygenation. The scope and limitations of the highly regio and diastereoselective reductive alkylation of malimides were defined. A remarkable protecting group effect on the regio and diastereoselective reductive alkylation of malimides was observed.
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