In this paper we study the Macroscopic Quantum Oscillation (MQO) e ect in ferromagnetic single domain magnets with a magnetic field applied along the hard anistropy axis. The level splitting for the ground state, derived with the conventional instanton method, oscillates with the external field and is quenched at some field values. A formula for quantum tunneling at excited levels is also obtained. The existence of topological phase accounts for this kind of oscillation and the corresponding thermodynamical quantities exhibit similar interference e ects which resembles to some extent the electron quantum phase interference induced by gauge potential in the Aharonov- Bohm effect and the-vacuum in Yang-Mills field theory.