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期刊论文
Enzyme-Catalyzed Synthesis of Some Vinyl Drug Esters in Organic Medium
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY Vol. 34, No.1, pp. 97-107, 2004，-0001，（）：
A series of vinyl drug esters was synthesized using acyclovir and chloramphenicol with different carbon chain length acyl donors by alkaline protease from Bacillus subtilis and Lipozymew respectively, in non-aqueous medium. The corresponding vinyl drug derivatives were confirmed by nuclear magnetic resonance and infrared spectrometry. The influences of different organic solvents, reaction time, temperature, and content of water on synthesis of vinyl chloramphenicol esters were studied.
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