Al2O3 material was synthesized by using high purity alumina micro-powder and Mg-Zr-Y composite additives at temperature of 1600℃, which had good mechanics property of 416MPa bending strength and 5.46MPa·m1/2 fracture tough-ness. Femur head prosthesis of hip joint was prepared by using this material; Ti alloy femur handle was sprayed bioactive hy-droxyapatite (HA) by plasma on surface, which improves the chemistry stability and biocompatibility of Ti alloy; eramic-metal combination artificial hip joint femur prosthesis was made by combining Al2O3 femur head with Ti alloy femur handle, so the manufacturing process is improved and the property and application flexibility are advanced.