Transportation system is regard as a part of lifeline earthquake engineering which is very important for earthquake resistant and reduction disaster. In this paper, three cases of transportation system are discussed, to analyze and study the reliability methods of components (road, street, bridge) in transportation system, network reliability way on the basis of units reliability regarded as control parameters, and the network optimum method. That will contribute a new theory base of reduction disaster plan to transportation system in pre-earthquake. After improvement of corresponding route according to the method presented in this paper, which will supply transportation system with elementary safety requirement for post-earthquake rescue under high seismic intensity disaster.