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期刊论文

Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling

刘锋Xiao-Peng Zhang Zhang Cheng Feng Liu* Wei Wang†

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摘要/描述

Interlinked positive feedback loops are frequently found in biological signaling pathways. It is intriguing to study the dynamics, functions, and robustness of these motifs. Using numerical simulations and theoretical analysis, here we explore the sensitiveness and robustness of positive feedback loops with various time scales. Both single and dual loops can behave as a bistable switch. We study the responses of five types of bistable switches to noisy stimuli. The noise-induced transitions between two states are discussed in detail by using energy landscape. The dual-time switch, consisting of interconnected fast and slow loops, is both sensitive to stimuli and resistant to fluctuations in stimulus. This provides a novel mechanism for creating optimal bistable switches and memory modules. Our results also suggest that the dual-time switch can act as a ubiquitous motif with sensitive robustness in biological systems.

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【免责声明】以下全部内容由[刘锋]上传于[2009年12月21日 17时23分43秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

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