We investigated possible therapeutic approaches to treat contagious naturally occurring ecthyma in Korean native goats in the Gongju area of Korea. Contagious ecthyma was found in 130 of 150 Korean native goats studied. Sixteen goats, ranged from 2 months to 2.5 years old, were selected for further experiments. The goats were divided into a control group, an ozonated oil group, and an ozonated water group consisting of 5, 5, and 6 goats, respectively. The control animals were not treated during the experimental period. The ozonated oil group was treated with ozonated oil, made by bubbling 200 ppm ozone gas into the oil, daily for 2 weeks. The remaining group of animals were given ozonated drinking water (0.1 ppm) ad libitum for 2 weeks. The ozonated oil treated group (4/5, 80%) had the highest therapeutic rate. The ozonated water group (4/6, 66.7%) had the second highest therapeutic rate, followed by the control group (1/5, 20%). Based on these results, a secondary experiment was performed that included a total of 121 Korean native goats with contagious ecthyma. Ozonated oil was applied daily for 30 days. All of the lesions on the goats with contagious ecthyma were completely cured by application of the ozonated oil. We concluded that ozone therapy was an effective treatment for contagious ecthyma in goats