Considering gravitational and gauge anomalies at the horizon, a new method that to derive Hawking radiations from black holes has been developed by Wilczek et al. In this paper, we apply this method to non-rotating and rotating Kaluza-Klein black holes with squashed horizon, respectively. For the rotating case, we found that, after the dimensional reduction, an effective U(1) gauge field is generated by an angular isometry. The results show that the gauge current and energy-momentum tensor fluxes are exactly equivalent to Hawking radiation from the event horizon.