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李孝红

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期刊论文

In Vitro Degradation and Release Profiles of Poly-DLLactide-Poly(ethylene glycol) Microspheres with Entrapped Proteins

李孝红， XIAOHONG LI ，， XIANMO DENG ， MINGLONG YUAN ， CHENGDONG XIONG ， ZHITANG HUANG ， YANHUA ZHANG ， WENXIANG JIA

Journal of Applied Polymer Science, Vol. 78, 140-148 (2000)，-0001，（）：

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摘要/描述

Poly-DL-lactide (PLA) and poly-DL-lactide-poly(ethylene glycol) (PELA) were produced by bulk ring-opening polymerization using stannous chloride as initiator. PLA, PELA microspheres, and PELA microspheres containing the outer membrane protein (OMP) of Leptospira interrogans with the size of 1.5-2mm were prepared by a solvent evaporation process. In vitro degradation and release tests of PLA, PELA, and OMP-loaded PELA microspheres were performed in pH 7.4 buffer solution at 37

关键词: poly-DL-lactide-poly( ， ethylene glycol) ，， degradation ， degradation mechanism ， protein release ， release mechanism

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