The effect of the mechanical failure of catalyst pellets on the pressure drop across a laboratory-scale catalyst packing has been examined by experiment. Results reveal that, along with the mechanical failure ofthe pellets, there exists a point ofmaximum curvature around which the slope of pressure drop increases rapidly. This rapid increase is attributed to a mutation of the packing structure, occurring as the amount off ailed pellets reaches a certain critical value. The secondary breakage ofthe pellets contributes much to the mutation of the packing and to the pressure drop. It has been observed that a trilobite catalyst is more susceptible to a mechanical stress than a cylindrical catalyst, and that a catalyst with a smaller diameter is much easier to result in an increase in the pressure drop. The measurement of the pressure drop across a laboratory-scale catalyst packing as the failure of pellets under a mechanical stress has a satisfactory reproducibility, and has a close meaning to the mechanical reliability of a: xed bed converter, and hence is recommended as a method for catalyst assessment. The multi-scale and multi-disciplinary nature ofcatalyst mechanical reliability is also discussed.