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引用
期刊论文
THE DESIGN AND SYNTHESIS OF ALS INHIBITORS FROM PHARMACOPHORE MODELS
Bioorganic & Medicinal Chemistry Letters 9(1999)1927-1932,-0001,():
In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was appfied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-datahase searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.
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