Applying the murine type 2 diabetesmodel induced by the intravenous injection of a small dose of strep tozotocin plus high fat high caloric laboratorycow, the animals w ere treated for 8 w eek s respectively with berberine and Huanglianjiedu decoction, and then murine serum glucose and lip id metabolic parameters were determ ined. It was demonstrated that in both Huanglianjiedu decoction and berberine groups the levels of serum total cholesterol, triglycerides, apolipop rotein B and fasting blood glucose were significantly decreased, while their high density lipop roteins-cholesterol and apolipop rotein A