提示
罗泽伟
-
76浏览
-
0点赞
-
0收藏
-
0分享
-
46下载
-
0评论
-
引用
期刊论文
Defective Expression of Transforming Growth Factor ? Receptor Type II Is Associated with CpG Methylated Promoter in Primary Non-Small Cell Lung Cancer
Vol. 10, 2359-2367, April 1, 2004，-0001，（）：
Purpose: Reduced expression of the transforming growth factor ? receptor type II (TGF ? RII), a key inhibitor of epithelial cell growth and tumor suppressor gene, was reported frequently in many types of tumors including nonsmall cell lung cancer (NSCLC). This study explored the significance of the TGF RII gene in NSCLC carcinogenesis. Experimental Design: With 43 independent pairs of tumor and paracarcinoma tissue samples from patients with primary NSCLC, we carried out PCR-denaturing gradient gel electrophoresis screening for DNA variants over the coding sequence of the TGF ? RII gene, immunohistochemical assay of TGF ? RII expression, methylation-specific PCR analysis, and semiquantitative reverse transcription-PCR.
【免责声明】以下全部内容由[罗泽伟]上传于[2010年11月29日 14时27分37秒]，版权归原创者所有。本文仅代表作者本人观点，与本网站无关。本网站对文中陈述、观点判断保持中立，不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考，并请自行承担全部责任。
本学者其他成果
同领域成果
