Liposome and PG kit were labeledwithg the 99m TcO4 to form 99m Tc-liposome and 99m Tc-PG which are two non-invasive, safe diagnostic drugs. The labeling efficiency of the agents are more than 95%. The 99m imaging agents in the PLN as compared with the other different organs showed that the ratio value of PLN to other organ ismore than 149 times after 30 min i.d. injection of 99m Tc-liposome and the ratio value is more than 30.19 times after 2h. i.d. injection of 99m Tc-PG. The studies of the pharmacokinetics and mechanism of imaging have been carried out. The 99m Tc-liposome was administrated to more than 140 patients and 99m Tc-PG was administratedto more than 5000 patients. The clinical tests were satisfactory and no side-effect was shown.