Purpose: To compare chemoembolization with conventional chemotheral chemotherapy and explore the possibility of chemoemmbolization in the oral and maxillofacial region using encased-anticancer-drug microspheres. METHOD: Six mongrel dogs were divided into two equal groups, an experi-mental group undergoing maxillofacial arteriaal chemoembolization with cisplatin encased in eth-yicellulose microspheres, and a control group undergoing the cnventional chmotherapy with cispllatin. The peripheral venous cisplatin concentration and the cisplatin concentration at the local tissue were determined. RESULT: The experiment showed a significant difference in the peripheral venous cisplatin concentration between the two groups and between the time period. There was also a significant interaction between groups and teme, The peak concentration in the experimental group appeared 12 to 24 hours after chemoembolization, The peak concentration in the control group appeared immediately after the anticancer drug was jnfused. Ther was a significant differencde in the concentration in the local tissue between the two groups, when all time periods were aggregated. CONCLUSION: Compared with conventionaal chemotherapy, the maxillofacial arteroal chemoernbolization with cisplatin encased in ethylcellulose microspheres significantly decreses the cisplatin concentration in the peripheral venous circulation and increases the concentration in tthe local tissues, allowing for the possibility of target cancer therapy.