In this paper, we consider the longtime dynamics of the solutions to focusing energy-critical Schrödinger equation with a defocusing energy-subcritical perturbation term under a ground state energy threshold in four spatial dimension. This extends the results in Miao et al. (Commun Math Phys 318(3):767–808, 2013, The dynamics of the NLS with the combined terms in five and higher dimensions. Some topics in harmonic analysis and applications, advanced lectures in mathematics, ALM34, Higher Education Press, Beijing, pp 265–298, 2015) to four dimension without radial assumption and the proof of scattering is based on the interactionMorawetz estimates developed in Dodson (Global well-posedness and scattering for the focusing, energy-critical nonlinear Schrödinger problem in dimension d = 4 for initial data below a ground state threshold, arXiv:1409.1950), the main ingredients of which requires us to overcome the logarithmic failure in the double Duhamel argument in four dimensions