The eastern part of Qilian Mountains experienced strong tectonic uplift during the late Quaternary, and climate record there was influenced by Tibetan Plateau to some extent. Based on studies on the fluvial terrace series and eolian loess deposition, we find that the tectonic uplifts of the Tibetan Plateau had coupled with climatic changes in our studied region and others since the mid-Pleistocene. The uplift that occurred at 0.83 Ma corresponded to significant desert expansion in L6 and periodic variation since MIS16, while the 0.14Ma one to the further drying in northwest China. Those coupled events may indicate that tectoni c uplift drove climatic changes, and the Tibetan Plateau has important impacts on East Asian Monsoon system.